131Iodine metaiodobenzylguanidine (MIBG) scintigraphy
Useful for the localization of certain types of NETs 1
Prior to scintigraphy with a planar gamma camera, patients are intravenously administered MIBG, which attaches to the tumor cells.2,3
NOTE: To block the uptake of free MIBG by the thyroid gland, patients should receive therapy with a solution of potassium iodide 1 day before and daily for 5 to 7 days after administration of the radioisotope.3
During the imaging process, MIBG competes with norepinephrine uptake and enters the metabolic pathway into and out of adrenergic tissues.3 MIBG scintigraphy may be less effective for identifying primary tumors than for identifying metastases.4
1. DRAXIMAGE MIBG [package insert]. Kirkland, Quebec, Canada: DRAXIMAGE, a division of DRAXIS Specialty Pharmaceuticals Inc; March 2006.
2. Medline Plus Medical Encyclopedia. MIBG scintiscan. http://www.nlm.nih.gov/medlineplus/ency/article
/003830.htm. Accessed April 29, 2010.
3. Hanson MW, Feldman JM, Blinder RA, Moore JD, Coleman RE. Carcinoid tumors: iodine-131 MIBG scintigraphy. Radiology. 1989;172(3):699-703.
4. Modlin IM, Kidd M, Latich I, Zikusoka MN, Shapiro MD. Current status of gastrointestinal carcinoids. Gastroenterology. 2005;128(6):1717-1751.