Endoscopic techniques

Endoscopy can be used to identify NETs in the stomach, duodenum, and rectum.1 Endoscopic ultrasound is another minimally invasive procedure that is useful in the localization and evaluation of pancreatic NETs,2,3 particularly when combined with fine-needle aspiration.3

Depending on the location of the NET, there are a number of endoscopic techniques that may aid in visualization.4-7

  • Flexible endoscopes can be used to view both the upper and lower GI tracts from the pharynx to the upper duodenum and beyond, and from the anus to the terminal ileum5
  • Device-assisted endoscopic techniques may allow visualization of the entire small bowel, along with the potential for biopsy to be performed. For example, double-balloon enteroscopy is a procedure in which a latex balloon is affixed to the distal ends of both endoscope and overtube. Coordinated inflation and deflation of the balloons aids in the advancement of the endoscope deep into the small intestine7
  • Capsule endoscopy (also called video capsule endoscopy) is an imaging technique in which the patient swallows a small, pill-shaped capsule that transmits video images as it travels through the GI tract. The capsule can also be inserted using an endoscope in patients who have difficulty swallowing6

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1. Jensen RT, Doherty GM. Carcinoid tumors and the carcinoid syndrome. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds. Cancer: Principles & Practice of Oncology. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:1559-1574.
2. Anderson MA, Carpenter S, Thompson NW, et al. Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. Am J Gastroenterol. 2000;95(9):2271-2277.
3. Chatzipantelis P, Salla C, Konstantinou P, Karoumpalis I, Sakellariou S, Doumani I. Endoscopic ultrasound-guided fine-needle aspiration cytology of pancreatic neuroendocrine tumors. A study of 48 cases. Cancer (Cancer Cytopathology). 2008;114(4):255-262.
4. Mamikunian G, Vinik AI, O'Dorisio TM, Woltering EA, Go VLW. Diagnosing and treating gastroenteropancreatic tumors, including ICD-9 codes. In: Neuroendocrine Tumors: A Comprehensive Guide to Diagnosis and Management. 4th ed. Inglewood, CA: Inter Science Institute; 2009:1-43.
5. Beers MH, Porter RS, Jones TV, Kaplan JL, Berkwits M, eds. The Merck Manual. 18th ed. Whitehouse Station, NJ: Merck Research Laboratories; 2006:85-86.
6. van Tuyl SAC, van Noorden JT, Timmer R, Stolk MFJ, Kuipers EJ, Taal BG. Detection of small-bowel neuroendocrine tumors by video capsule endoscopy. Gastrointest Endosc. 2006;64(1):66-72.
7. Ross A, Mehdizadeh S, Tokar J, et al. Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy. Dig Dis Sci. 2008;53(8):2140-2143.
4. Mamikunian G, Vinik AI, O'Dorisio TM, Woltering EA, Go VLW. Diagnosing and treating gastroenteropancreatic tumors, including ICD-9 codes. In: Neuroendocrine Tumors: A Comprehensive Guide to Diagnosis and Management. 4th ed. Inglewood, CA: Inter Science Institute; 2009:1-43.
5. Beers MH, Porter RS, Jones TV, Kaplan JL, Berkwits M, eds. The Merck Manual. 18th ed. Whitehouse Station, NJ: Merck Research Laboratories; 2006:85-86.
6. van Tuyl SAC, van Noorden JT, Timmer R, Stolk MFJ, Kuipers EJ, Taal BG. Detection of small-bowel neuroendocrine tumors by video capsule endoscopy. Gastrointest Endosc. 2006;64(1):66-72.
7. Ross A, Mehdizadeh S, Tokar J, et al. Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy. Dig Dis Sci. 2008;53(8):2140-2143.